Constipation Drugs

Constipation Drugs

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Constipation Drugs

  • Constipation occur when stool becomes hard and difficult to pass.
  • Common cause of constipation are – inadequate fluid intake, food habits, immobility, medication and endocrine or metabolic disorders etc.

 

Constipation drugs Classification

  • Purgative (cathartics)
  • Laxatives (aperient)
  • Laxative drugs cause the mild action and eliminate of soft and formed stool.
  • Purgative drugs cause the strong action, resulting in more fluid evacuation.

 

  1. Bulk forming laxatives drugs

  • Methylcellulose
  • Dietary fibers – like – fruits, oats, etc.
  • Isapghulla – 3 – 12 gm – The drug swell and softens the stool.

 

  1. Stimulant purgatives

The drug irritate GI mucosa

Increase secretion and motility of stool

To promote bowel evacuation

 

  • Bisacodil – 5 mg.
  • Glycerol
  • Sinna (plants leaves)
  • Danthron

 

  1. Stool softness 

  • Docusate sodium – 100 – 400 mg.
  • Liquid paraffin (mineral oil) 15 – 30 ml.

 

  1. Osmotic purgatives

  • Lactolose – in children = 5 – 30 ml
    • In adult = 5 – 30 ml.

 

Lactolus retain water in intestinal lumen

Increase bulk of the stool and increase the peristalsis

Evacuation of stool

Constipation drug indication

  • Constipation
  • Pregnancy
  • Drug-induced constipation
  • Bedridden patient
  • Immobilized patient (paralysis patient)
  • Food and drug poisoning
  • Colonoscopy and radioscopy procedure
  • Post-operative patient.

 

 

Constipation drug Adverse effects 

    • GI irritation, dehydration
    • Rectal burning sensation
    • Bloating, cramping, diarrhea
    • Thirst, electrolyte imbalance, etc.

 

Constipation drugs Key Points

  1. Antimotility drugs is a – Opioid drug
  2. Most commonly used antimotility drug – Loperamide
  3. Common constipation drugs is – Purgative and Laxatives.
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